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Modulating the thermoresponsive characteristics of PLGA-PEG-PLGA hydrogels via manipulation of PLGA monomer sequences
SeongHoon Jo, Soonjong Roh, Jaemin Shim, Ji Woong Yu, Youngmee Jung, Woo Young Jang, Bumjoon Seo*, You-Yeon Won*, Jin Yoo*
Abstract
In a temperature-responsive polymer gel, experiments and particle-based simulations show that the order of its molecular building blocks changes how aggregates called micelles connect and merge, shifting gel formation and drug release.